To test whether LRRC4 affected the communication between GBM cells and CD4+CCR4+ T cells through exosomes, we isolated exosomes from the conditioned medium of U251 Tet-on-LRRC4 and PG-LRRC4/CON cells (Figure 2A) and verified that these exosomes were transmitted into TILs (Figure 2B). The gene discussed is CCR4; the disease is glioblastoma.