Interestingly, although LRRC4 did not alter PDL-1 expression in GBM cells (Figure 2Ib,c), LRRC4 inhibited PDL-1 that was packed into exosomes (Figure 2Id) and reduced the transmission of PDL-1 from GBM cells to TILs. The gene discussed is CD274; the disease is glioblastoma.