In doxycycline (DOX)-induced U251 Tet-on-LRRC4 cells and PG-LRRC4 GBM cells, LRRC4 resulted in increased expression and secretion of interleukin-6 (IL-6) and interferon gamma (IFN-g) (Figure 1I). This evidence concerns the gene LRRC4 and glioblastoma.