Previous studies have confirmed that LRRC4 is a tumor suppressor gene for glioma, is capable of regulating miR-182 and miR-381 and constitutes multiphase circuits with transcription factors, gene methylation modifications and miRNAs in GBMs, such as the LRRC4/NGL-2-miR-185/SP1-DNMT1-LRRC4/NGL-2 loop and the LRRC4/NGL-2-AP-2-miR-182-LRRC4/NGL-2 loop. This evidence concerns the gene LRRC4 and central nervous system cancer.