Primary cells DLBCL.2 and BL were clustered together with increased expression of CADM1, SLAMF-7, CD59, and MICB observed in BL primary cells; increased expression of CD58, ITGAM, FAS, and HLA-C in DLBCL.2 and BL primary cells; and increased expression of CD48, HLA-E, ITGAL, CLEC2B, CLEC2D, SLAMF6, ITGB2, and LGALS1 in DLBCL.2 cells. Here, HLA-C is linked to diffuse large B-cell lymphoma.