In addition, low expression of NKp46 has been reported as an “evasion mechanism” associated with low cell activity in cancer (70), mainly following chronic stimulation (71), or described as an “exhausted” profile in chronically infected patients (72, 73), patients with cancer (Kaposi sarcoma, PTLD) (74, 75), a mechanism involved in peripheral tolerance. The gene discussed is NCR1; the disease is cancer.