Moreover, antibodies against two HTLV-1 viral products, Tax and Gag p24, have been reported to cross-react with host antigens, heterogeneous ribonucleoprotein A1 (hnRNP A1) and peroxiredoxin-1 (PrX-1), respectively, suggesting that molecular mimicry may play a role in the pathogenesis of HAM/TSP, suggesting a role for molecular mimicry between an infectious agent and the CNS (Levin et al., 2002; Lee et al., 2008). Here, CNTN2 is linked to tropical spastic paraparesis.