The latter were obtained from mice that develop spontaneous B cell lymphomas as a result of deregulated expression of BCL6 under the immunoglobulin (Ig) heavy chain Iμ promoter and of deregulated activation of the alternative NF-κB pathway by expression of the NF-κB inducing kinase (NIK) under the ROSA26 promoter (Zhang et al., 2015). The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.