When infected by apple stem grooving virus (ASGV), apple genes encoding PR proteins PR1 and PR1a were up-regulated (Chen et al., 2014); similarly, PR1 expression in tomato was also induced by infection with tomato spotted wilt virus (TSWV) (López-Gresa et al., 2016) and CEVd (Conejero et al., 1990; López-Gresa et al., 2016). This evidence concerns the gene TMEM37 and infection.