The GDM patients group retaining higher plasmatic levels of miR-330-3p showed signs of a more aggressive diabetic phenotype; indeed they were more likely to require future insulin therapy respect to GDM-miR-330low whose glycemic control was guaranteed by diet indications only; moreover, the rate of those GDM patients having one or more T2D relatives was higher in GDM-miR-330high (Table 3). Here, INS is linked to gestational diabetes.