Our results show that a change in glucose stimulus similar to the one during development of T2DM, i.e., exposure of islets to non-oscillatory and slightly elevated glucose concentration, leads to an excess of large events in the spatiotemporal pattern of fast [Ca2+]c oscillations that are believed to determine the pulse mass of insulin oscillations, suggesting that a switch to supercriticality might be an important pathophysiological mechanism in T2DM. Here, INS is linked to type 2 diabetes mellitus.