While the cardiovascular benefits of statins in the T1D population are well-known (Peto et al., 2002; Cholesterol Treatment Trialists' (CTT) Collaborators, 2008), this is the first study, to our knowledge, that investigates the effects of statins on changes in PAI-1 for the restoration of tissue repair in T1D. This evidence concerns the gene SERPINE1 and type 1 diabetes mellitus.