In the EMPA-REG OUTCOME trial, empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter 2 (SGLT2), reduced the risk of the combined endpoint of hospitalization for heart failure or cardiovascular death, in type 2 diabetic patients (T2D) (Fitchett et al., 2016). The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.