Because there is no information on possible beneficial effects of exercise training on BBB leakage in the SHR (the best model of essential hypertension), we sought to evaluate in autonomic brain areas: (i) the changes on both BBB permeability and circulatory autonomic control induced by training starting in the chronic phase of hypertension; (ii) the combined effect of both training and elevated brain Ang II content on BBB permeability. The gene discussed is AGT; the disease is Hypertension.