IL22 and chronic rhinosinusitis without nasal polyps: This was confirmed by another study by Wang et al however, there are conflicting reports about cytokine IL-22 levels, with one study showing no statistical difference in IL-22 levels between patient groups and the other finding IL-22 was significantly higher in CRSsNP mucosa compared to controls (Ramanathan et al., 2007; Wang et al., 2014).