TNFAIP3 and cancer: Zinc finger protein A20 (tumor necrosis factor alpha-induced protein 3), a potent negative feedback inhibitor of the NF-κB signaling, has been widely reported in auto-inflammatory disease (Zilberman-Rudenko et al., 2016), stroke (Zhan et al., 2016), cancer (Chen et al., 2015), and AS (Wolfrum et al., 2007).