Therefore, strategies by using low dose of a TGF-β inhibitor, LY364947 was developed to reduce the pericyte coverage of endothelium and increase size gaps between endothelium to increase therapeutic benefits of gemcitabine-loaded liposomes for pancreatic cancer (Cabral et al., 2011; Meng et al., 2013) and Doxil for diffuse-type gastric cancer (Kano et al., 2007). This evidence concerns the gene TGFB1 and pancreatic neoplasm.