Some possible mechanisms are as follows: First, radiation could upregulate the level of vascular endothelial growth factor (VEGF) by activating hypoxia inducible factor 1 (HIF1) (Moeller et al., 2004; Stapleton et al., 2016) or via multiple mitogen-activated protein kinase dependent pathways (Park et al., 2001) to increase the permeability of tumor vessels (Kobayashi et al., 2004). This evidence concerns the gene VEGFA and neoplasm.