Other studies showed that the VDR ligand and all-trans retinoic acid (ATRA) can act through VDR or Wnt-β-Catenin signaling pathway to reprogram PSC to the quiescent state to reduce the fibrotic content in tumor interstitium (Froeling et al., 2011; Sherman et al., 2014; Chronopoulos et al., 2016), which is promising for the second-wave nanomedicine therapy. Here, VDR is linked to neoplasm.