DAVID database pathway enrichment analysis showed that the top five pathways of YPFS regulating asthma were NOD-like receptor signaling pathway, tumor necrosis factor (TNF) signal pathway, phosphatidylinositol-3-kinase (PI3K)-AKT signal pathway, Hypoxia-inducible factor (HIF)-1 signal pathway and nuclear factor-kappaB (NF-κB) signal pathway (Table 1). The gene discussed is TNF; the disease is asthma.