NLRP3 and asthma: Moreover, previous clinical and experimental studies demonstrated that the expression of NLRP3 inflammasome was up-regulated in patients with asthma and OVA-induced asthma model (Kim et al., 2017; Rossios et al., 2017), which indicated NLRP3 inflammasome played an important role in the pathology of asthma (Simpson et al., 2014).