Nuclear receptors and transcription factors such as pregnane X receptor (PXR), farnesoid X receptor (FXR), constitutive androstane receptor (CAR), and nuclear factor-E2-related factor-2 (Nrf2), which regulate these genes, may be potential therapeutic targets in cholestasis (Weerachayaphorn et al., 2012; Chen et al., 2014). The gene discussed is NR1I3; the disease is cholestasis.