LY294002 was shown to markedly promote the BD-induced cellular apoptosis, PI3K/Akt inactivation, and up-regulate the pro-caspase-3 and pro-caspase-9 expression, implying that the PANC-1 and Capan-2 cellular apoptosis evoked by BD was mediated, at least partially, via the PI3K/Akt signaling pathway (Figures 4A–D and Supplementary Figure S3). This evidence concerns the gene CASP9 and Behcet disease.