CASP3 and Behcet disease: Moreover, our results indicated that the down-regulation of PI3K/Akt activation, modulation of expression of apoptosis-regulated gene products such as pro-caspase 3, pro-caspase 9, Bcl-2, Bcl-xL, Survivin, XIAP, and the activation of MAPKs were responsible for the therapeutic effects of BD in xenograft model (Figures 7D,E).