Our result gained further insight into the time- and dose-dependent anti-PanCa effect of BD, and provided pioneering evidence that BD significantly suppressed the tumor growth, inhibited the proliferative index and induced caspases/mitochondria-dependent apoptosis through suppressing the activation of PI3K/Akt and MAPKs both in vivo and in vitro. Here, AKT1 is linked to Behcet disease.