We have determined that CGA has an anti-liver fibrosis effect on schistosome-infected mice by suppressing the IL-13/miR-21/Smad7 signaling interactions (Wang et al., 2017) and has an anti-inflammatory effect through the suppression of the TLR2/TLR9-Myd88 signaling pathways (Guo et al., 2015a). Here, SMAD7 is linked to Hepatic fibrosis.