To assess whether the disruption of the NFAT1-MDM2 P2 promoter complex by InuA could inhibit MDM2 transcription, we examined the MDM2 mRNA expression and the protein expression of NFAT1 and MDM2 in prostate cancer cells transfected with NFAT1 siRNA or control siRNA. This evidence concerns the gene MDM2 and Familial prostate cancer.