Effect of SFN on four breast cancer cell lines showed abnormalities in ErbB2/ER-PI3K-Akt-mTOR-S6K1 signaling pathway as reported by Pawlik et al. The breast cancer cell lines used include, MDA MB 468, MDA MB 231, SKBR3, and MCF-7. This evidence concerns the gene ERBB2 and breast cancer.