AKT1 and cancer: Previous studies revealed the induction of autophagy by PLB in different cancer cell lines via the negative PI3K/Akt/mTOR axis modulation (Kuo et al., 2006; Li et al., 2014) As per Wang's previous data autophagy was induced through inhibition of the PI3K/Akt/mTOR pathway in non-small-cell lung cancer cells.