AKT1 and plasma cell myeloma: It was hypothesized that PI3K/Akt signaling pathway exhibited a crucial role in programmed cell death in HL-60 from previous studies, induction of apoptosis through the PI3K/Akt pathway in HT-29 human colorectal cancer cells (Kim et al., 2012) and in a human myeloma cell line (Zhang et al., 2013).