TRIM63 and Cachexia: It is known that NF-κB upregulated the expression of MuRF1 (Li and Reid, 2000; Bodine et al., 2001; Vallabhapurapu and Karin, 2009) and suppressed MyoD mRNA at the posttranscriptional level in muscle decay and cachexia (Guttridge et al., 2000).