INS and prediabetes syndrome: In the same work, we described that bilateral CSN resection prevents the development of dysmetabolic changes induced by hypercaloric diets (Ribeiro et al., 2013) and more recently we have demonstrated that bilateral, but not unilateral CSN resection, restores insulin sensitivity and glucose homeostasis in prediabetes and type 2 diabetic rats (Sacramento et al., 2017a,b) suggesting that CB modulation could be used as a therapeutic approach.