Similarly, hexahydrocurcumin inhibits COX-2 expression and induces cell cycle arrest in human CRC SW480 cells (Chen C.Y. et al., 2011) and octahydrocurcumin suppresses NF-κB activity (Pan et al., 2000) and scavenges free radicals (Somparn et al., 2007). This evidence concerns the gene NFKB1 and colorectal carcinoma.