CYP19A1 and Alzheimer disease: Depletion of aromatase in an animal model of AD also led to earlier and more severe neuropathology than what was observed in OVX control mice, suggesting that depletion of brain-derived estrogen rather that peripheral blood estrogen is a more direct and significant risk factor for developing AD and points to the importance of preserving neurosteroidogenesis for healthy brain aging (Cui et al., 2013).