In addition, nuclear transcription factor-κB (NF-κB) plays a central role in the PD pathogenesis by inducing the expression of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) via oxidative stress mediated neurodegeneration (Hald and Lotharius, 2005). The gene discussed is NFKB1; the disease is Parkinson disease.