The “dual” association of the mesial temporal structural and functional findings with amyloid (significant correlation with SUVR) on the one hand and with tau (regional preference, neurodegeneration) on the other hand is interesting because it ties into the observation that amyloid facilitates the development of widespread tau pathology that characterizes the clinical manifest stages of AD (Musiek and Holtzman, 2015). This evidence concerns the gene MAPT and Alzheimer disease.