Accordingly, haploinsufficient IGF-1 availability causes growth retardation and has been associated with short adult stature and hearing loss in other genetic syndromes such as Noonan's or Turner' syndromes (Barrenäs et al., 2000, 2005b; Welch and Dawes, 2007; El Bouchikhi et al., 2016). The gene discussed is IGF1; the disease is hearing loss disorder.