RBFOX3 and Alzheimer disease: Staining of human temporal lobe neocortical sections from control and age- and gender-matched AD brains with anti-LPS fluorescent antibodies showed detectable signals in both cases, however the control LPS signals (Figures 1A–C) were more disperse and punctate while the AD LPS signals (Figures 1D–F) were more self-associating, globular and abundant, and were almost always associated with NeuN- and DAPI-staining neuronal nuclei (Supplementary Figure S1; see Figure 2).