RBFOX3 and Alzheimer disease: In order to investigate how LPS may be associating with neuronal nuclei, a series of temporal lobe neocortical sections from control and age-matched AD brains were stained with LPS and a DAPI nuclear stain (control Figures 2A,E; AD Figures 2C,G) as well as the neuron-specific stain NeuN (control Figures 2B,F; AD Figures 2D,H); the results of two control brains (both female; mean age 85.5 ± 3.1 years and PMI 3 h or less; Figures 2A,B,E,F) and two AD brains (both female age 86.5 ± 2.5 years and PMI 3 h or less; Figures 2C,D,G,H) are representative of assays on multiple brains (N = 12).