GSTM1 and spindle cell hemangioma: Recently, studies have also addressed the role of the Hb/LHb in higher brain functions such as reward, emotion, learning and memory, sleep and wakefulness (Yang et al., 2008; Shen et al., 2012; Zhao et al., 2015; Zhang et al., 2016; Li et al., 2017), dysfunctions of which are associated with the pathogenesis of SCH (Levesque et al., 2012; Lee et al., 2015; Ferrarelli and Tononi, 2017).