P2RX3 and ischemia: Other models show significant increases in the expression of P2X3/4/5, ASIC3 and P2Y1, which have also been linked to muscle afferent function, pain manifestation and EPR modulation post ischemia (McCord et al., 2009, 2010; Liu et al., 2010; Seo et al., 2010; Queme et al., 2016; Ross et al., 2016).