KCNQ4 and Anxiety: Following the same line of thinking, we expect that the current finding that Kv7.4 is an important modulator of 5-HT neurons would be translated into novel Kv7.4-based treatments of diseases characterized by 5-HT neuronal overactivity, such as anxiety and fear (Korsgaard et al., 2005; Maier and Watkins, 2005).