Neuroinflammation in AD is characterized by the accumulation of cytokines such as IL-1β, IL-6, TNF-α, or TGF-β, which can contribute with cerebral amyloid deposition, augmentation of APP expression, Aβ formation, and subsequent recruitment and activation of microglial cells (Esler and Wolfe, 2001). This evidence concerns the gene APP and Alzheimer disease.