DIXDC1 and cancer: Dixdc1, a gene that encodes a transcription factor that is a positive regulator of the Wnt signaling pathway (Chen et al., 2017), was up-regulated in the Hedgehog-activation group, and recent studies have shown that inhibition of Dixdc1 protein can suppress the proliferation of cancer cells (Chen et al., 2017; Zhong et al., 2017).