Since the PD-linked LRRK2-G2019S mutant is associated with shorter neurite development in culture (MacLeod et al., 2006; Winner et al., 2011; Sepulveda et al., 2013), we then tested whether active PAK6 rescues the G2019S-associated neurite shortening phenotype in BAC G2019S mice overexpressing murine LRRK2-G2019S. Here, LRRK2 is linked to Parkinson disease.