Here we used the BAC-mLRRK2G2019S mouse (Li et al., 2010), which was previously shown to display the neurite shortening phenotype (Sepulveda et al., 2013) and to show signs of neurodegeneration in the substantia nigra pars compacta at 18 months of age (Chen et al., 2017), to investigate the potential implication of our findings in LRRK2-PD. This evidence concerns the gene LRRK2 and Parkinson disease.