One of best characterized phenotype caused by mutant LRRK2 in neurons is a reduction of neurite complexity (MacLeod et al., 2006; Sepulveda et al., 2013; Matikainen-Ankney et al., 2016), which may represent an early event before neuronal degeneration and motor dysfunction observed in some PD-LRRK2 models (Li et al., 2010; Melrose et al., 2010; Winner et al., 2011; Longo et al., 2014; Beccano-Kelly et al., 2015; Yue et al., 2015; Adeosun et al., 2017). This evidence concerns the gene LRRK2 and Parkinson disease.