Alterations in the catalytic activity of 69-kDa ChAT are found in a number of neurological disorders, including Alzheimer's disease (AD) (Pakaski and Kalman, 2008), amyotrophic lateral sclerosis (Kato, 1989) and Huntington's disease (Lange et al., 1992). The gene discussed is CHAT; the disease is Alzheimer disease.