An early study showed that activation of the TRPM2 channel mediates ROS-induced cell death (Hara et al., 2002) and recent studies using transgenic TRPM2-knockout (TRPM2-KO) mice have revealed a critical role for ROS-induced TRPM2-mediated cell death in diverse cell types that contributes to pathologies such as diabetes (Manna et al., 2015), ischemic kidney damage (Gao et al., 2014) and paracetamol-induced liver injury (Kheradpezhouh et al., 2014). This evidence concerns the gene TRPM2 and diabetes mellitus.