Furthermore, TRPM2-dependent neuronal death has been related to post-ischemia brain damage (Jia et al., 2011; Nakayama et al., 2013; Shimizu et al., 2013, 2016; Ye et al., 2014) and Alzheimer’s disease (Ostapchenko et al., 2015). The gene discussed is TRPM2; the disease is ischemia.