CREB3L1 and central nervous system cancer: In C6 glioma cells and cultured astrocytes, early studies showed that Creb3l1 was involved in the unfolded protein response (UPR), identifying ER chaperone protein 78-kDa glucose-regulated protein (Grp78) as a target of Creb3l1 effects (Murakami et al., 2006).