Studies of other neurological disease models have shown that TLR4 plays an important role in the pathogenesis of a variety of neuro-inflammation and is expressed in microglia and neurons (Wang et al., 2014; Baek et al., 2017; Chen et al., 2017; Lawrimore and Crews, 2017; Rocha Sobrinho et al., 2017). The gene discussed is TLR4; the disease is nervous system disorder.