APOE and Alzheimer disease: (2) As expected, concentrations of total amyloid beta and amyloid β-42 were significantly greater in AD and mixed subjects but low in post-stroke subjects consistent with insufficient concentrations for a diagnosis of AD (3) an association between APOE ε4 allele positivity and higher load of amyloid and tau pathology in the subiculum and entorhinal cortex of post-stroke cases (4) hyperphosphorylated tau immunoreactivity did not differ significantly between PSND and PSD groups and (5) poor correlation of cognitive measures with the burden of amyloid and tau pathology in post-stroke subjects.