MAPT and Alzheimer disease: A recent study in which total and phosphorylated tau proteins were quantified in the frontal and temporal cortices of subjects with vascular dementia found a selective loss of total tau protein in VaD compared with controls and AD, whereas phosphorylated tau levels were similar to controls in VaD in both regions, but they were increased in the temporal lobes of patients with AD (Mukaetova-Ladinska et al., 2015).