In order to investigate the effect of APOE4 expression in an AD-vulnerable vs. an AD-resistant brain region, RNA-sequencing was performed on RNA extracted from the EC and PVC of 14–15 month-old APOE targeted replacement mice expressing human APOE3/4 (19 males) vs. APOE3/3 (10 males). The gene discussed is APOE; the disease is Alzheimer disease.