In order to test the hypothesis that altered de novo sphingolipid synthesis might play a pivotal role in the control of cellular homeostasis and survival in HD cells, WT (STHdh7/7) cells, which normally display lower susceptibility to apoptosis (Maglione et al., 2010; Di Pardo et al., 2014) than HD (STHdh111/111) cells, were treated with myriocin, a selective SPT inhibitor (Hanada et al., 2000). This evidence concerns the gene AGXT and Huntington disease.