SPTLC1 and Huntington disease: Sptlc1 mRNA levels were significantly increased in HD mice with respect to WT littermates in both brain regions (striatum: 1.018 ± 0.1931 vs. 1.511 ± 0.4457; p = 0.0293; Unpaired t-test; Figure 6A) (cortex: 1.008 ± 0.1397 vs. 1.295 ± 0.2780, p = 0.0476, Unpaired t-test; Figure 6B).