qPCR analysis showed a significant reduction of mRNA expression levels of sptlc1 in HD mice with respect to WT littermates in both striatum (1.021 ± 0.2262 vs. 0.7553 ± 0.1246; p = 0.0219, Unpaired t-test; Figure 2A) and cortex (1.016 ± 0.1131 vs. 0.8225 ± 0.12149; p = 0.0081, Unpaired t-test; Figure 2B). Here, SPTLC1 is linked to Huntington disease.