Results of these studies were controversial, with some stipulating that TREM2 in microglia increase phagocytosis and clearance of Aβ (Wang et al., 2015; Xiang et al., 2016; Yuan et al., 2016), while others have suggested that disruption of TREM2 reduces amyloid plaque load (Ulrich et al., 2014; Jay et al., 2015; Krasemann et al., 2017). This evidence concerns the gene TREM2 and amyloidosis.