AKT1 and breast cancer: Likewise, the antiproliferative action of breast cancer cells by adiponectin is mediated by an inactivation of protein 1 and 3 expression in MAPK p44/42, a stimulation of AMPK activity and a decrease in phosphorylation of Akt, associated with an increased expression of LKB1, reducing the activity of mTOR and leading to a decrease in the production of reactive oxygen species [19, 27–29].