COQ5 and allergic rhinitis: Out of the disease phenotypes incorporated into our study, intermittent allergic rhinitis (IAR in vitro) had the most significant gene (COQ5 [Coenzyme Q5, Methyltransferase], a gene involved in methyltransferase activity) with a FDR value of 2.4E-09 (mean difference = 105 units, or affected twins had higher gene expression than their unaffected twin pair).