SYT11 and Parkinson disease: Interestingly, the conditional overexpression of Syt11 in SNpc DA neurons induced a dramatic decrease in ipsilateral striatal DA release (Fig. 8c) and an imbalance of contralateral motor stability (Fig. 8d–f), indicating that the accumulation of Syt11 in SNpc DA neurons is sufficient to mediate PD-related toxicity as well.