SYT11 and Parkinson disease: Strikingly, unilateral overexpression of the C2B-truncated form of Syt11 in the SNpc (Fig. 6b–d) failed to impair the ipsilateral striatal DA release (Fig. 6e, f) and the contralateral motor stability (Fig. 6g–k), indicating the critical role of the C2B domain in the Syt11-mediated pathogenesis of PD.