Our study reveals functional connectivity of the two PD-risk genes (parkin and SYT11) involving dysfunctional dopamine transmission, which is likely a common pathogenic pathway shared by other PD-risk genes (i.e. synaptojanin 1, α-synuclein, TMEM230, and LRRK2)3,33,34,43–46. Here, SYNJ1 is linked to Parkinson disease.