However, given the strikingly high HO-1 expression in bone lesions revealed by cBioPortal analyses, the fact that our own immunohistochemical examination of bone tissues demonstrated high HO-1 levels in metastatic tumor cells, and the well-established evidence that more than 80% of metastatic prostate cancer patients present with bone lesions, the importance of this enzyme in bone-metastatic disease is clearly underscored. The gene discussed is HMOX1; the disease is metastatic prostate carcinoma.