Additional cBioPortal polyA transcriptome analysis of RNA-seq filtered for mRNA from the Metastatic Prostate Cancer, SU2C/PCF Dream Team cohort showed that across multiple metastatic tumor sites in patients there is strikingly high expression of HO-1 in bone lesions compared to other distal sites collected (Supplementary Figure 1). The gene discussed is HMOX1; the disease is metastatic neoplasm.