Similarly, a comparable induction of IFN-α and IFN-β was observed in the culture supernatants of M. tuberculosis-infected macrophages carrying TCC/TCC or TCC/Del IFNAR1 (Supplementary Fig. 2b), suggesting that the TCC/Del in IFNAR1 does not appear to impact type I IFN production in TB patients and M. tuberculosis-infected macrophages. The gene discussed is IFNAR1; the disease is tuberculosis.