EPHX2 and depressive disorder: In another study that used lipopolysaccharide-induced inflammation and repeated social defeat stress models, pretreatment with an sEH inhibitor and sEH KO were found to prevent the onset of depression-like behaviors and to increase BDNF-TrkB expression in the prefrontal cortex and the hippocampus, suggesting that BDNF-TrkB signaling confers the stress resilience in association with sEH blockade19.