EPHX2 and ischemic stroke: Compared to wild-type (WT) controls, sEH KO mice had smaller infarcts in association with increased EET levels and collateral blood flow11,12, In contrast, transgenic mice with endothelial-specific overexpression of human sEH exhibited impaired vasodilatation and enlarged infarcts after MCAO in female but not in male mice17, suggesting that sEH may serve as a vasoactive modulator and a potential therapeutic target in ischemic stroke.