Further evaluation of the role of these proteins in breast cancer, osteoclastogenesis and/or osteoblast differentiation revealed a subset of 21 proteins that are likely to be implicated in the regulation of the TRAF2-driven breast cancer-induced osteoclast and osteoblast changes that we have observed in our models (Fig. 3H and Table S2). This evidence concerns the gene TRAF2 and breast carcinoma.