Microarray analysis of secreted proteins in conditioned medium from osteotropic MDA-231-BT overexpressing TRAF2 indicates that these effects were likely due to increase in the level of tumour-derived NFκB-mediated osteolytic factors, such as TNFα, IL-1, granulate macrophage colony stimulating factor (GM-CSF), M-CSF, CD40L, IL-17, IL-11, vascular endothelial growth factor (VEGF) (Table S1). The gene discussed is TNF; the disease is neoplasm.