The anti-oxidant response associated with p62 can contribute to tumor progression in the liver as addressed by two significant researches; one is that p62 is induced by carcinogen treatment in mice and promotes its mitogenic activity8, and the other is that mutations of NRF2 and KEAP1 account for approximately 6% and 4% of cases in HCC, respectively26. The gene discussed is SQSTM1; the disease is hepatocellular carcinoma.