DEPDC5 and hepatocellular carcinoma: While Burza et al. have recently reported that DEPDC5 knockdown increases the expression levels of β-catenin and downstream genes of Wnt/β-catenin pathway in hepatic stellate cells14, the gene set enrichment analysis showed significant correlation between the expression of DEPDC5 and enhanced mTORC1 activity as well as anti-oxidative capacity, rather than Wnt/β-catenin pathway in the DEPDC5-KO HCC cells (Supplementary Fig. 2).