Among 85 mutations (missense 77; stop-gain 6; start-loss 1; start-gain 1) of DEPDC5 identified in HCC specimens registered on the ICGC Data Portal, stop-gain mutations were concentrated in the DUF5803 domain (Fig. 1a), which aids in binding to the other components of the GATOR1 complex. The gene discussed is DEPDC5; the disease is hepatocellular carcinoma.