The reasons for DEPDC5 deficiency in liver cancer are as follows; the public data of The Cancer Genome Atlas (TCGA) project identified mutations of DEPDC5 in eight cases (2.1%; missense 7; stop-gain 1) of HCC specimens and worse overall survival of patients with DEPDC5 mutation (Supplementary Fig. 4a). Here, DEPDC5 is linked to hepatocellular carcinoma.